Independent executive advisory
Helping biotech and life sciences leaders turn strategic ambition into investment discipline, organisational readiness and measurable business value.
For biotech founders, leadership teams and investors.
The value creation lens
Better decisions. Stronger execution.
Bringing strategy, investment and operating performance into one practical conversation.
01
Strategic priorities
↓ Focus resources on what matters
02
Investment & execution
↓ Establish ownership and accountability
03
Measurable value
The challenge
As biotech companies grow and investor expectations rise, the quality of strategic and operational decisions becomes increasingly important.
I bring a practical, financially grounded perspective to the questions that shape growth and value creation.
01 / PRIORITIES
Are we investing in the right priorities?
02 / VALUE
Will our business case translate into realised value?
03 / SCALE
Is our operating model ready for the next stage of growth?
04 / DELIVERY
Do we have the governance and accountability to execute?
Advisory services
Focused support for the decisions, capabilities and governance that help turn ambition into outcomes.
Investment-to-Impact Diagnostic
Identify gaps between strategic priorities, investment decisions and execution. Establish the actions that can make the greatest difference.
Business Case & Value Realisation
Strengthen assumptions, clarify benefit ownership and establish practical ways to track and realise expected value.
Portfolio Prioritisation
Make trade-offs visible, compare competing initiatives and direct resources towards the highest-value opportunities.
Operating Model & Scale-up
Align decision rights, governance, capabilities and ways of working with the organisation’s next stage of growth.
Fractional Executive Advisor
Provide experienced senior-level challenge and ongoing support for strategic decisions, transformation and performance.
Growth & Investor Readiness
Assess alignment between growth plans, operating capabilities, governance and upcoming business milestones.
Who I help
Advisory shaped around the decisions facing the people building biotech businesses and the investors supporting them.
For founders & leadership teams
Build the business to match the science.
Navigate growth, focus limited resources, strengthen governance and prepare the organisation for its next stage.
For investors & boards
Turn investment theses into value creation.
Support portfolio-company prioritisation, execution readiness and the operating disciplines that help deliver against expectations.
Executive experience
Irena Prášilová brings more than 25 years of experience across MSD and Accenture, working at the intersection of finance, investment governance, portfolio leadership and organisational transformation.
Her work has involved complex investment decisions, operating-model changes, multinational teams and the challenge of translating strategic priorities into measurable outcomes.
Through Prasilova Advisory, she brings that executive perspective to biotech and life sciences companies and their investors.
Figures below describe previous portfolio and budget responsibilities; they are not biotech-specific performance claims.
$300M
Technology investment portfolio managed
$200M
Annual Opex stewardship
$100M
Annual Capex stewardship
90
People in teams led
How I work
Advisory should make complex decisions clearer and leave leadership teams better equipped to act.
01. Clarify what matters
Understand the business context, strategic choices and the outcomes that matter most.
02. Align decisions and ownership
Connect priorities, resources, governance and clear accountability for delivery.
03. Focus on realised value
Establish practical measures and review mechanisms to keep progress visible.
Beyond advisory
Two passions run alongside my advisory work: sharing knowledge on conference stages and helping people make better decisions, build confidence and navigate their careers in a supportive environment.
Speaking & knowledge sharing
Turning experience into insight.
I speak at conferences and professional forums about portfolio decision-making, prioritisation, transformation and turning investment into measurable value. I value the exchange of experience—sharing practical lessons, asking better questions and learning from others across industries.
Mentoring & women’s development
Helping people make better decisions—and learn safely.
Mentoring is a personal passion: creating space for people to reflect, test ideas, learn from experience and make career decisions with greater confidence. I especially enjoy supporting women as they develop their voice, recognise their strengths and navigate professional challenges.
Mentoring communities: Odyssey (Czech), Equilibrium by BCC and Together2Grow.
Start a conversation
Whether you are building a biotech company, preparing for the next stage of growth or supporting a portfolio company, let’s discuss the challenge you are facing.
Email Irena ↗